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Anti-CYP19A1 Antibody

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产品名称: Anti-CYP19A1 Antibody
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简单介绍

Anti-CYP19A1 Antibody


Anti-CYP19A1 Antibody  的详细介绍
Name: Anti-CYP19A1 Antibody
See all CYP19A1 primary antibodies
Description: Rabbit polyclonal antibody to CYP19A1
Specificity: CYP19A1 Polyclonal Antibody detects endogenous levels of CYP19A1 protein.
Applications: WB, IHC, IF, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the Internal region of human CYP19A1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Tissue Specificity: Widely expressed, including in ***** and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
Involvement in Disease: Aromatase excess syndrome: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.

Aromatase deficiency: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In ***** females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
Sequence Similarities: Belongs to the cytochrome P450 family.
Post-Translational Modification: Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 1588?Human
  • Entrez Gene: 13075?Mouse
  • Entrez Gene: 25147?Rat
  • Omim: 107910?Human
  • SwissProt: P11511?Human
  • SwissProt: P28649?Mouse
  • SwissProt: P22443?Rat
  • Unigene: 260074?Human
  • Unigene: 478781?Mouse
  • Unigene: 5199?Mouse
  • Unigene: 21402?Rat
    		•
    Synonyms:
  • ARO Antibody
  • ARO1 Antibody
  • Aromatase Antibody
  • CP19A_HUMAN Antibody
  • CPV1 Antibody
  • CYAR Antibody
  • CYP19 Antibody
  • Cyp19a1 Antibody
  • CYPXIX Antibody
  • Cytochrome P-450AROM Antibody
  • Cytochrome P450 19A1 Antibody
  • Cytochrome P450, family 19, subfamily A, polypeptide 1 Antibody
  • Cytochrome P450, subfamily XIX (aromatization of androgens) Antibody
  • Estrogen synthase Antibody
  • Estrogen synthetase Antibody
  • Flavoprotein linked monooxygenase Antibody
  • MGC104309 Antibody
  • Microsomal monooxygenase Antibody
  • OTTHUMP00000162543 Antibody
  • OTTHUMP00000198350 Antibody
  • P 450AROM Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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