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Anti-CYP11A1 Antibody

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产品名称: Anti-CYP11A1 Antibody
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简单介绍

Anti-CYP11A1 Antibody


Anti-CYP11A1 Antibody  的详细介绍
Name: Anti-CYP11A1 Antibody
See all CYP11A1 primary antibodies
Description: Rabbit polyclonal antibody to CYP11A1
Specificity: CYP11A1 pAb detects endogenous levels of CYP11A1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human CYP11A1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 60 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Involvement in Disease: Adrenal insufficiency, congenital, with 46,XY sex reversal: A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia.
Sequence Similarities: Belongs to the cytochrome P450 family.
Cellular Location: Mitochondrion membrane.
Database Links:
  • Entrez Gene: 1583?Human
  • Entrez Gene: 13070?Mouse
  • Entrez Gene: 29680?Rat
  • Omim: 118485?Human
  • SwissProt: P05108?Human
  • SwissProt: Q9QZ82?Mouse
  • SwissProt: P14137?Rat
  • Unigene: 303980?Human
  • Unigene: 302865?Mouse
  • Unigene: 1401?Rat
    		•
    Synonyms:
  • Cholesterol 20 22 desmolase Antibody
  • Cholesterol desmolase Antibody
  • Cholesterol monooxygenase (side chain cleaving) Antibody
  • Cholesterol side chain cleavage enzyme Antibody
  • Cholesterol side chain cleavage enzyme mitochondrial Antibody
  • Cholesterol side-chain cleavage enzyme Antibody
  • CP11A_HUMAN Antibody
  • CYP11A Antibody
  • CYP11A1 Antibody
  • CYPXIA1 Antibody
  • Cytochrome P450 11A1 Antibody
  • Cytochrome P450 11A1 mitochondrial Antibody
  • Cytochrome P450 family 11 subfamily A polypeptide 1 Antibody
  • Cytochrome P450 subfamily XIA Antibody
  • Cytochrome P450(scc) Antibody
  • Cytochrome P450C11A1 Antibody
  • mitochondrial Antibody
  • P450SCC Antibody
  • Steroid 20 22 lyase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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