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Anti-CYP11A1 Antibody

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产品名称: Anti-CYP11A1 Antibody
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简单介绍

Anti-CYP11A1 Antibody


Anti-CYP11A1 Antibody  的详细介绍
Name: Anti-CYP11A1 Antibody
See all CYP11A1 primary antibodies
Description: Rabbit polyclonal antibody to CYP11A1.
Applications: WB, IF
Dilutions: WB: 1:500 - 1:2000, IF: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human CYP11A1.
Protein Length: 521
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Involvement in Disease: Adrenal insufficiency, congenital, with 46,XY sex reversal: A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia.
Sequence Similarities: Belongs to the cytochrome P450 family.
Cellular Location: Mitochondrion membrane.
Database Links:
  • Entrez Gene: 1583 Human
  • Entrez Gene: 13070 Mouse
  • Entrez Gene: 29680 Rat
  • Omim: 118485 Human
  • SwissProt: P05108 Human
  • SwissProt: Q9QZ82 Mouse
  • SwissProt: P14137 Rat
  • Unigene: 303980 Human
  • Unigene: 302865 Mouse
  • Unigene: 1401 Rat
    		•
    Synonyms:
  • Cholesterol 20 22 desmolase Antibody
  • Cholesterol desmolase Antibody
  • Cholesterol monooxygenase (side chain cleaving) Antibody
  • Cholesterol side chain cleavage enzyme Antibody
  • Cholesterol side chain cleavage enzyme mitochondrial Antibody
  • Cholesterol side-chain cleavage enzyme Antibody
  • CP11A_HUMAN Antibody
  • CYP11A Antibody
  • CYP11A1 Antibody
  • CYPXIA1 Antibody
  • Cytochrome P450 11A1 Antibody
  • Cytochrome P450 11A1 mitochondrial Antibody
  • Cytochrome P450 family 11 subfamily A polypeptide 1 Antibody
  • Cytochrome P450 subfamily XIA Antibody
  • Cytochrome P450(scc) Antibody
  • Cytochrome P450C11A1 Antibody
  • mitochondrial Antibody
  • P450SCC Antibody
  • Steroid 20 22 lyase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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