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Anti-CYLD Antibody

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Anti-CYLD Antibody


Anti-CYLD Antibody  的详细介绍
Name: Anti-CYLD Antibody
See all CYLD primary antibodies
Description: Rabbit polyclonal antibody to CYLD
Specificity: The antibody detects endogenous levels of total CYLD protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human cylindromatosis (turban tumor syndrome)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.3mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26670046, PubMed:26997266).
Tissue Specificity: Detected in fetal brain, testis, and skeletal muscle, and at a lower level in ***** brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney.
Involvement in Disease: Cylindromatosis, familial: A disorder characterized by multiple skin tumors that develop from skin appendages, such as hair follicles and sweat glands. Affected individuals typically develop large numbers of tumors called cylindromas that arise predominantly in hairy parts of the body with approximately 90% on the head and neck. In severely affected individuals, cylindromas may combine into a confluent mass which may ulcerate or become infected (turban tumor syndrome). Individuals with familial cylindromatosis occasionally develop other types of tumors including spiradenomas that begin in sweat glands, and trichoepitheliomas arising from hair follicles.

Multiple familial trichoepithelioma 1: Autosomal dominant dermatosis characterized by the presence of many skin tumors predominantly on the face. Since histologic examination shows dermal aggregates of basaloid cells with connection to or differentiation toward hair follicles, this disorder has been thought to represent a benign hamartoma of the pilosebaceous apparatus. Trichoepitheliomas can degenerate into basal cell carcinoma.

Brooke-Spiegler syndrome: An autosomal dominant disorder characterized by the appearance of multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma. These tumors are typically located in the head and neck region, appear in early *****hood, and gradually increase in size and number throughout life.
Sequence Similarities: Belongs to the peptidase C19 family.
Post-Translational Modification: Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli. Phosphorylation requires IKBKG. Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B.
Cellular Location: Cytoplasm. Cytoplasm > Perinuclear region. Cytoplasm > Cytoskeleton. Cell membrane. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Cytoplasm > Cytoskeleton > Cilium basal body.

Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. During metaphase, it remains localized to the centrosome but is also present along the spindle (PubMed:25134987).
Database Links:
  • Entrez Gene: 1540?Human
  • Omim: 605018?Human
  • SwissProt: Q9NQC7?Human
  • Unigene: 578973?Human
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    Synonyms:
  • BRSS Antibody
  • CDMT Antibody
  • CYLD Antibody
  • CYLD gene Antibody
  • CYLD1 Antibody
  • CYLDI Antibody
  • CYLD_HUMAN Antibody
  • cylindromatosis (turban tumor syndrome) Antibody
  • cylindromatosis 1 Antibody
  • Deubiquitinating enzyme CYLD Antibody
  • EAC Antibody
  • HSPC057 Antibody
  • KIAA0849 Antibody
  • MFT Antibody
  • MFT1 Antibody
  • Probable ubiquitin carboxyl terminal hydrolase CYLD Antibody
  • SBS Antibody
  • TEM Antibody
  • turban tumor syndrome Antibody
  • Ubiquitin carboxyl-terminal hydrolase CYLD Antibody
  • ubiquitin specific peptidase like 2 Antibody
  • ubiquitin thioesterase CYLD Antibody
  • Ubiquitin thiolesterase CYLD Antibody
  • Ubiquitin-specific processing protease CYLD Antibody
  • Ubiquitin-specific-processing protease CYLD Antibody
  • USPL2 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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