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Anti-Cyclophilin F (Y121) Antibody

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产品名称: Anti-Cyclophilin F (Y121) Antibody
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Anti-Cyclophilin F (Y121) Antibody


Anti-Cyclophilin F (Y121) Antibody  的详细介绍
Name: Anti-Cyclophilin F (Y121) Antibody
See all Cyclophilin F primary antibodies
Description: Rabbit polyclonal antibody to Cyclophilin F (Y121)
Specificity: Cyclophilin F (Y121) pAb detects endogenous levels of Cyclophilin F protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 91-140 of Human Cyclophilin F.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 22 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Sequence Similarities: Belongs to the cyclophilin-type PPIase family.
Post-Translational Modification: Deacteylated at Lys-167 by SIRT3.
Cellular Location: Mitochondrion matrix.
Database Links:
  • Entrez Gene: 10105?Human
  • Entrez Gene: 105675?Mouse
  • Entrez Gene: 282819?Rat
  • Omim: 604486?Human
  • SwissProt: P30405?Human
  • SwissProt: Q99KR7?Mouse
  • SwissProt: P29117?Rat
  • Unigene: 381072?Human
  • Unigene: 41656?Mouse
  • Unigene: 2923?Rat
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    Synonyms:
  • Cyclophilin 3 Antibody
  • cyclophilin D Antibody
  • Cyclophilin F Antibody
  • Cyp D Antibody
  • CyP M Antibody
  • CYP3 Antibody
  • CypD Antibody
  • hCyP3 Antibody
  • mitochondrial Antibody
  • Mitochondrial cyclophilin Antibody
  • Peptidyl prolyl cis trans isomerase, mitochondral Antibody
  • Peptidyl-prolyl cis-trans isomerase F Antibody
  • Peptidyl-prolyl cis-trans isomerase F, mitochondrial Antibody
  • Peptidylprolyl isomerase F Antibody
  • Peptidylprolyl isomerase F (cyclophilin F) Antibody
  • PPIase Antibody
  • PPIase F Antibody
  • Ppif Antibody
  • PPIF_HUMAN Antibody
  • Rotamase Antibody
  • Rotamase F Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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