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Anti-Cyclin L1 (E491) Antibody

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产品名称: Anti-Cyclin L1 (E491) Antibody
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Anti-Cyclin L1 (E491) Antibody


Anti-Cyclin L1 (E491) Antibody  的详细介绍
Name: Anti-Cyclin L1 (E491) Antibody
See all Cyclin L1 primary antibodies
Description: Rabbit polyclonal antibody to Cyclin L1 (E491)
Specificity: Cyclin-L1 (E491) pAb detects endogenous levels of Cyclin-L1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 460-518 of Human Cyclin L1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 60 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).
Tissue Specificity: Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Sequence Similarities: Belongs to the cyclin family. Cyclin L subfamily.
Cellular Location: Nucleus speckle. Nucleus > Nucleoplasm.

Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
Database Links:
  • Entrez Gene: 57018?Human
  • Entrez Gene: 56706?Mouse
  • Entrez Gene: 114121?Rat
  • Omim: 613384?Human
  • SwissProt: Q9UK58?Human
  • SwissProt: Q52KE7?Mouse
  • SwissProt: Q9R1Q2?Rat
  • Unigene: 4859?Human
  • Unigene: 175612?Mouse
  • Unigene: 12962?Rat
    		•
    Synonyms:
  • Ania 6a Antibody
  • CCNL1 Antibody
  • CCNL1_HUMAN Antibody
  • Cyclin L Antibody
  • Cyclin L gamma Antibody
  • Cyclin L1 Antibody
  • Cyclin-L Antibody
  • Cyclin-L1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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