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Anti-CYB5R3 Antibody

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产品名称: Anti-CYB5R3 Antibody
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Anti-CYB5R3 Antibody


Anti-CYB5R3 Antibody  的详细介绍
Name: Anti-CYB5R3 Antibody
See all CYB5R3 primary antibodies
Description: Goat polyclonal antibody to CYB5R3.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human CYB5R3 (C terminal).
Sequence: CLPNLDHVGHPTER
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Tissue Specificity: Isoform 2 is expressed at late stages of erythroid maturation.
Involvement in Disease: Methemoglobinemia CYB5R3-related: A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.
Sequence Similarities: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Cellular Location: Endoplasmic reticulum membrane. Mitochondrion outer membrane.
Database Links:
  • Entrez Gene: 1727?Human
  • Omim: 613213?Human
  • SwissProt: P00387?Human
  • Unigene: 561064?Human
    		•
    Synonyms:
  • B5R Antibody
  • CYB5R3 Antibody
  • Cytochrome b5 reductase Antibody
  • Cytochrome b5 reductase 3 Antibody
  • DIA1 Antibody
  • Diaphorase 1 Antibody
  • Diaphorase-1 Antibody
  • NADH cytochrome b5 reductase 3 Antibody
  • NADH-cytochrome b5 reductase 3 membrane-bound form Antibody
  • NADH-cytochrome b5 reductase 3 soluble form Antibody
  • NB5R3_HUMAN Antibody
  • OTTHUMP00000028761 Antibody
  • OTTHUMP00000198435 Antibody
  • OTTHUMP00000198574 Antibody
  • OTTHUMP00000198662 Antibody
  • OTTHUMP00000198665 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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