产品资料

Anti-CXCR4 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-CXCR4 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-CXCR4 Antibody


Anti-CXCR4 Antibody  的详细介绍
Name: Anti-CXCR4 Antibody
See all CXCR4 primary antibodies
Description: Rabbit polyclonal antibody to CXCR4
Specificity: No reaction to the 84 kDa STAT1a.
Applications: E, WB, ICC, IP, IF, FC
Reactivity: Human, Mouse
Immunogen: Raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: DEAE purified
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
Tissue Specificity: Lymphocytes, macrophages, neutrophils, microglial cells and astrocytes. Found in spleen, thymus, bone marrow, lymph nodes and, at lower levels in brain, small intestine, stomach and kidney. CXCR4-A is predominant in all tissues tested. During embryonic development, high levels are detected in the endothelium of developing blood vessels and in many regions of the developing brain including the olfactory epithelium, olfactory bulb, hippocampus, cerebellum and spinal cord.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-331 and Ser-332 leads to recruitment of ITCH, ubiquitination and protein degradation (By similarity).
Cellular Location: Cell membrane. Cell junction. Early endosome. Late endosome. Lysosome.

In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).
Database Links:
  • Entrez Gene: 7852 Human
  • Entrez Gene: 12767 Mouse
  • Omim: 162643 Human
  • SwissProt: P61073 Human
  • SwissProt: P70658 Mouse
  • Unigene: 593413 Human
  • Unigene: 1401 Mouse
    		•
    Synonyms:
  • C-X-C chemokine receptor type 4 Antibody
  • CD184 Antibody
  • CD184 antigen Antibody
  • Chemokine (C X C motif) receptor 4 Antibody
  • Chemokine CXC Motif Receptor 4 Antibody
  • CXC-R4 Antibody
  • CXCR-4 Antibody
  • CXCR4 Antibody
  • CXCR4_HUMAN Antibody
  • D2S201E Antibody
  • FB22 Antibody
  • Fusin Antibody
  • HM89 Antibody
  • HSY3RR Antibody
  • LAP 3 Antibody
  • LAP3 Antibody
  • LCR1 Antibody
  • LESTR Antibody
  • Leukocyte derived seven transmembrane domain receptor Antibody
  • Leukocyte-derived seven transmembrane domain receptor Antibody
  • Lipopolysaccharide associated protein 3 Antibody
  • Neuropeptide Y receptor Y3 Antibody
  • NPY3R Antibody
  • NPYR Antibody
  • NPYRL Antibody
  • NPYY3 Antibody
  • NPYY3R Antibody
  • Probable G protein coupled receptor lcr1 homolog Antibody
  • SDF 1 receptor Antibody
  • SDF-1 receptor Antibody
  • SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR Antibody
  • Stromal cell derived factor 1 receptor Antibody
  • Stromal cell-derived factor 1 receptor Antibody
  • WHIM Antibody
  • WHIMS Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号