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Anti-CXCR4 (phospho-S339) Antibody

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产品名称: Anti-CXCR4 (phospho-S339) Antibody
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Anti-CXCR4 (phospho-S339) Antibody


Anti-CXCR4 (phospho-S339) Antibody  的详细介绍
Name: Anti-CXCR4 (phospho-S339) Antibody
See all CXCR4 primary antibodies
Description: Rabbit polyclonal antibody to CXCR4 (phospho-S339)
Specificity: p-CXCR4 (S339) pAb detects endogenous levels of CXCR4 protein only when phosphorylated at Ser339.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human CXCR4 around the phosphorylation site of Serine 339.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 40-47 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
Tissue Specificity: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
Involvement in Disease: WHIM syndrome: Immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.
Cellular Location: Cell membrane. Cell junction. Early endosome. Late endosome. Lysosome.

In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Database Links:
  • Entrez Gene: 7852 Human
  • Entrez Gene: 12767 Mouse
  • Entrez Gene: 60628 Rat
  • Omim: 162643 Human
  • SwissProt: P61073 Human
  • SwissProt: P70658 Mouse
  • SwissProt: O08565 Rat
  • Unigene: 593413 Human
  • Unigene: 1401 Mouse
  • Unigene: 44431 Rat
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    Synonyms:
  • C-X-C chemokine receptor type 4 Antibody
  • CD184 Antibody
  • CD184 antigen Antibody
  • Chemokine (C X C motif) receptor 4 Antibody
  • Chemokine CXC Motif Receptor 4 Antibody
  • CXC-R4 Antibody
  • CXCR-4 Antibody
  • CXCR4 Antibody
  • CXCR4_HUMAN Antibody
  • D2S201E Antibody
  • FB22 Antibody
  • Fusin Antibody
  • HM89 Antibody
  • HSY3RR Antibody
  • LAP 3 Antibody
  • LAP3 Antibody
  • LCR1 Antibody
  • LESTR Antibody
  • Leukocyte derived seven transmembrane domain receptor Antibody
  • Leukocyte-derived seven transmembrane domain receptor Antibody
  • Lipopolysaccharide associated protein 3 Antibody
  • Neuropeptide Y receptor Y3 Antibody
  • NPY3R Antibody
  • NPYR Antibody
  • NPYRL Antibody
  • NPYY3 Antibody
  • NPYY3R Antibody
  • Probable G protein coupled receptor lcr1 homolog Antibody
  • SDF 1 receptor Antibody
  • SDF-1 receptor Antibody
  • SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR Antibody
  • Stromal cell derived factor 1 receptor Antibody
  • Stromal cell-derived factor 1 receptor Antibody
  • WHIM Antibody
  • WHIMS Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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