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Anti-CX3CR1 Antibody

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产品名称: Anti-CX3CR1 Antibody
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简单介绍

Anti-CX3CR1 Antibody


Anti-CX3CR1 Antibody  的详细介绍
Name: Anti-CX3CR1 Antibody
See all CX3CR1 primary antibodies
Description: Rabbit polyclonal antibody to CX3CR1
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Raised against a peptide corresponding to amino acids in a extracellular loop of human CX3CR1. The sequence is identical to that of rat CX3CR1 and differs from that of mouse CX3CR1 by one amino acid.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932).
Tissue Specificity: Expressed in lymphoid and neural tissues.
Involvement in Disease: Macular degeneration, age-related, 12: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification: This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 1524?Human
  • Omim: 601470?Human
  • SwissProt: P49238?Human
  • Unigene: 78913?Human
    		•
    Synonyms:
  • Beta chemokine receptor-like 1 Antibody
  • C X3 C CKR 1 Antibody
  • C-X3-C CKR-1 Antibody
  • CCRL1 Antibody
  • Chemokine C X3 C motif receptor 1 Antibody
  • CMK BRL 1 Antibody
  • CMK-BRL-1 Antibody
  • CMK-BRL1 Antibody
  • CMKBLR1 Antibody
  • CMKDR1 Antibody
  • CX3C chemokine receptor 1 Antibody
  • CX3C CKR1 Antibody
  • CX3C1_HUMAN Antibody
  • CX3CR1 Antibody
  • Fractalkine receptor Antibody
  • G-protein coupled receptor 13 Antibody
  • GPR13 Antibody
  • GPRV28 Antibody
  • V28 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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