产品资料

Anti-CSPG4 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-CSPG4 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-CSPG4 Antibody


Anti-CSPG4 Antibody  的详细介绍
Name: Anti-CSPG4 Antibody
See all CSPG4 primary antibodies
Description: Rabbit polyclonal antibody to CSPG4
Specificity: The antibody detects endogenous levels of total CSPG4 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.6mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
Tissue Specificity: Detected only in malignant melanoma cells.
Post-Translational Modification: O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.
Cellular Location: Cell membrane. Apical cell membrane. Cell projection > Lamellipodium membrane. Cell surface.

Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).
Database Links:
  • Entrez Gene: 1464?Human
  • Entrez Gene: 121021?Mouse
  • Entrez Gene: 81651?Rat
  • Omim: 601172?Human
  • SwissProt: Q6UVK1?Human
  • SwissProt: Q8VHY0?Mouse
  • SwissProt: Q00657?Rat
  • Unigene: 513044?Human
  • Unigene: 41329?Mouse
  • Unigene: 10381?Rat
    		•
    Synonyms:
  • 4732461B14Rik Antibody
  • AN2 Antibody
  • AN2 proteoglycan Antibody
  • Chondroitin sulfate proteoglycan 4 Antibody
  • Chondroitin sulfate proteoglycan 4 (melanoma-associated) Antibody
  • Chondroitin sulfate proteoglycan NG2 Antibody
  • Cspg4 Antibody
  • Cspg4 chondroitin sulfate proteoglycan 4 Antibody
  • CSPG4_HUMAN Antibody
  • HMW-MAA Antibody
  • HSN tumor-specific antigen Antibody
  • Kiaa4232 Antibody
  • MCSP Antibody
  • MCSPG Antibody
  • MEL-CSPG Antibody
  • Melanoma chondroitin sulfate proteoglycan Antibody
  • Melanoma-associated chondroitin sulfate proteoglycan Antibody
  • MELCSPG Antibody
  • MSK16 Antibody
  • NG2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号