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Anti-CSNK2A2 Antibody

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产品名称: Anti-CSNK2A2 Antibody
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Anti-CSNK2A2 Antibody


Anti-CSNK2A2 Antibody  的详细介绍
Name: Anti-CSNK2A2 Antibody
See all CSNK2A2 primary antibodies
Description: Rabbit polyclonal antibody to CSNK2A2
Specificity: CSNK2A2 pAb detects endogenous levels of CSNK2A2 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human CSNK2A2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 41 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Database Links:
  • Entrez Gene: 1459?Human
  • Entrez Gene: 13000?Mouse
  • Omim: 115442?Human
  • SwissProt: P19784?Human
  • SwissProt: O54833?Mouse
  • Unigene: 82201?Human
  • Unigene: 440348?Mouse
  • Unigene: 51136?Mouse
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    Synonyms:
  • Casein kinase 2 alpha prime polypeptide Antibody
  • Casein kinase II alpha' chain Antibody
  • Casein kinase II subunit alpha' Antibody
  • CK II Antibody
  • CK II alpha' Antibody
  • CK2A2 Antibody
  • CKII Antibody
  • CKII alpha prime polypeptide Antibody
  • CSK22_HUMAN Antibody
  • CSNK2A1 Antibody
  • CSNK2A2 Antibody
  • FLJ43934 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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