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Anti-CSNK1G2 Antibody

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产品名称: Anti-CSNK1G2 Antibody
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简单介绍

Anti-CSNK1G2 Antibody


Anti-CSNK1G2 Antibody  的详细介绍
Name: Anti-CSNK1G2 Antibody
See all CSNK1G2 primary antibodies
Description: Rabbit polyclonal antibody to CSNK1G2.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human
Immunogen: Recombinant protein of human CSNK1G2.
Protein Length: 415
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Tissue Specificity: Testis.
Sequence Similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Post-Translational Modification: Autophosphorylated.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 1455?Human
  • Omim: 602214?Human
  • SwissProt: P78368?Human
  • Unigene: 651905?Human
    		•
    Synonyms:
  • Casein Kinase 1 gamma 2 Antibody
  • Casein kinase 1, gamma 2 Antibody
  • Casein kinase I isoform gamma 2 Antibody
  • Casein kinase I isoform gamma-2 Antibody
  • CK1g2 Antibody
  • CKI gamma 2 Antibody
  • CKI-gamma 2 Antibody
  • CSNK1G 2 Antibody
  • Csnk1g2 Antibody
  • KC1G2_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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