产品资料

Anti-Csk (L558) Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-Csk (L558) Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-Csk (L558) Antibody


Anti-Csk (L558) Antibody  的详细介绍
Name: Anti-Csk (L558) Antibody
See all Csk primary antibodies
Description: Rabbit polyclonal antibody to Csk (L558)
Specificity: Csk (L558) pAb detects endogenous levels of Csk protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human Csk.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 50 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Tissue Specificity: Expressed in lung and macrophages.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Post-Translational Modification: Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
Cellular Location: Cytoplasm. Cell membrane.

Mainly cytoplasmic, also present in lipid rafts.
Database Links:
  • Entrez Gene: 1445?Human
  • Entrez Gene: 12988?Mouse
  • Entrez Gene: 315707?Rat
  • Omim: 124095?Human
  • SwissProt: P41240?Human
  • SwissProt: P41241?Mouse
  • SwissProt: P32577?Rat
  • Unigene: 77793?Human
  • Unigene: 21974?Mouse
  • Unigene: 470150?Mouse
  • Unigene: 2759?Rat
    		•
    Synonyms:
  • C SRC Antibody
  • C SRC kinase Antibody
  • C src Tyrosine Kinase Antibody
  • C-SRC kinase Antibody
  • c-src tyrosine kinase Antibody
  • CSK Antibody
  • Csk A Antibody
  • CSK_HUMAN Antibody
  • CYTOPLASMIC TYROSINE KINASE Antibody
  • EC 2.7.10.2 Antibody
  • MGC112926 Antibody
  • MGC117393 Antibody
  • MGC154049 Antibody
  • P60 Src Antibody
  • Protein tyrosine kinase CYL Antibody
  • Protein-tyrosine kinase CYL Antibody
  • Proto oncogene tyrosine protein kinase Antibody
  • Tyrosine protein kinase CSK Antibody
  • Tyrosine-protein kinase CSK Antibody
  • zgc:154049 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号