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Anti-CRK Antibody

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产品名称: Anti-CRK Antibody
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简单介绍

Anti-CRK Antibody


Anti-CRK Antibody  的详细介绍
Name: Anti-CRK Antibody
See all CRK primary antibodies
Description: Rabbit polyclonal antibody to CRK
Specificity: The antibody detects endogenous levels of total CRK protein.
Applications: IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human v-crk avian sarcoma virus CT10 oncogene homolog
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Sequence Similarities: Belongs to the CRK family.
Post-Translational Modification: Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.
Cellular Location: Cytoplasm. Cell membrane.

Translocated to the plasma membrane upon cell adhesion.
Database Links:
  • Entrez Gene: 1398?Human
  • Omim: 164762?Human
  • SwissProt: P46108?Human
  • Unigene: 638121?Human
    		•
    Synonyms:
  • Adapter molecule crk Antibody
  • Avian sarcoma virus CT10 (v crk) oncogene homolog Antibody
  • CRK Antibody
  • CRK isoform 2 Antibody
  • CRK isoform II Antibody
  • Crk p38 Antibody
  • CRKII Antibody
  • CRK_HUMAN Antibody
  • FLJ38130 Antibody
  • OTTHUMP00000115366 Antibody
  • OTTHUMP00000198330 Antibody
  • p38 Antibody
  • Proto oncogene C crk Antibody
  • Proto-oncogene C-crk Antibody
  • v crk avian sarcoma virus CT10 oncogene homolog Antibody
  • v crk sarcoma virus CT10 oncogene homolog Antibody
  • v crk sarcoma virus CT10 oncogene homolog (avian) Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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