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Anti-CREB3L2 Antibody

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产品名称: Anti-CREB3L2 Antibody
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Anti-CREB3L2 Antibody


Anti-CREB3L2 Antibody  的详细介绍
Name: Anti-CREB3L2 Antibody
See all CREB3L2 primary antibodies
Description: Goat polyclonal antibody to CREB3L2.
Applications: ELISA, WB
Reactivity: Mouse, Rat
Immunogen: Synthetic peptide corresponding to Human CREB3L2 (internal region).
Sequence: C-HSLQEPYTASVVRS
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
Sequence Similarities: Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification: Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2).
Cellular Location: Endoplasmic reticulum membrane.

ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus.
Database Links:
  • Entrez Gene: 208647 Mouse
  • Entrez Gene: 362339 Rat
  • SwissProt: Q8BH52 Mouse
  • SwissProt: Q6QDP7 Rat
  • Unigene: 169929 Mouse
  • Unigene: 482172 Mouse
  • Unigene: 23031 Rat
    		•
    Synonyms:
  • B ZIB transcription factor Antibody
  • Basic transcription factor 2 Antibody
  • BBF2 human homolog on chromosome 7 Antibody
  • BBF2H7 Antibody
  • BZIB transcription factor Antibody
  • cAMP responsive element binding protein 3 like 2 Antibody
  • cAMP-responsive element-binding protein 3-like protein 2 Antibody
  • CR3L2_HUMAN Antibody
  • CREB3L2 Antibody
  • Cyclic AMP-responsive element-binding protein 3-like protein 2 Antibody
  • FUS/BBF2H7 protein Antibody
  • MGC131709 Antibody
  • MGC71006 Antibody
  • Processed cyclic AMP-responsive element-binding protein 3-like protein 2 Antibody
  • TCAG_1951439 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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