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Anti-CREB3 Antibody

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产品名称: Anti-CREB3 Antibody
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简单介绍

Anti-CREB3 Antibody


Anti-CREB3 Antibody  的详细介绍
Name: Anti-CREB3 Antibody
See all CREB3 primary antibodies
Description: Rabbit polyclonal antibody to CREB3
Specificity: The antibody detects endogenous level of total CREB3 antibody.
Applications: WB, IF
Reactivity: Human
Immunogen: Recombinant protein of human CREB3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.
Tissue Specificity: Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous.
Sequence Similarities: Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification: The ER membrane embedded cyclic AMP-responsive element-binding protein 3 form is first proteolytically cleaved by site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly induced during dendritic cell (DC) maturation and inhibited by TM7SF4.
Cellular Location: Endoplasmic reticulum membrane. Membrane.

Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with TM7SF4 in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. Sequestred into the cytoplasm by the HCV core protein.
Database Links:
  • Entrez Gene: 10488 Human
  • Omim: 606443 Human
  • SwissProt: O43889 Human
    		•
    Synonyms:
  • Basic leucine zipper protein Antibody
  • cAMP responsive element binding protein 3 Antibody
  • Clic AMP responsive element binding protein 3 Antibody
  • CREB 3 Antibody
  • CREB3 Antibody
  • cyclic AMP response element (CRE) binding protein/activating transcription factor 1 Antibody
  • Cyclic AMP responsive element binding protein 3 Antibody
  • Leucine zipper protein Antibody
  • LUMAN Antibody
  • LZIP Antibody
  • MGC15333 Antibody
  • MGC19782 Antibody
  • Transcription factor LZIP alpha Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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