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Anti-COPS5 Antibody

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产品名称: Anti-COPS5 Antibody
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Anti-COPS5 Antibody


Anti-COPS5 Antibody  的详细介绍
Name: Anti-COPS5 Antibody
See all COPS5 primary antibodies
Description: Rabbit polyclonal antibody to COPS5
Specificity: COPS5 pAb detects endogenous levels of COPS5 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human COPS5.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 38 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
Sequence Similarities: Belongs to the peptidase M67A family. CSN5 subfamily.
Cellular Location: Cytoplasm. Nucleus. Cytoplasm > Perinuclear region. Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle.

Nuclear localization is diminished in the presence of IFIT3.
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