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Anti-COPS2 Antibody

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产品名称: Anti-COPS2 Antibody
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简单介绍

Anti-COPS2 Antibody


Anti-COPS2 Antibody  的详细介绍
Name: Anti-COPS2 Antibody
See all COPS2 primary antibodies
Description: Rabbit polyclonal antibody to COPS2
Specificity: The antibody detects endogenous level of total COPS2 polyclonal antibody.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Recombinant human COP9 signalosome complex subunit 2 protein (1-310aa)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen Affinity Purified
Concentration: 1.0mg / mL
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20?C
Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Sequence Similarities: Belongs to the CSN2 family.
Post-Translational Modification: Phosphorylated by CK2 and PKD kinases.
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 9318?Human
  • Entrez Gene: 12848?Mouse
  • Omim: 604508?Human
  • SwissProt: P61201?Human
  • SwissProt: P61202?Mouse
  • Unigene: 369614?Human
  • Unigene: 3596?Mouse
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    Synonyms:
  • ALIEN Antibody
  • Alien Drosophila himolog of Antibody
  • Alien homolog Antibody
  • COP 9 Antibody
  • COP9 Antibody
  • COP9 constitutive photomorphogenic homolog subunit 2 Antibody
  • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) Antibody
  • COP9 signalosome complex subunit 2 Antibody
  • COPS 2 Antibody
  • Cops2 Antibody
  • CSN2 Antibody
  • CSN2_HUMAN Antibody
  • JAB1 containing signalosome subunit 2 Antibody
  • JAB1-containing signalosome subunit 2 Antibody
  • SGN 2 Antibody
  • SGN2 Antibody
  • Signalosome subunit 2 Antibody
  • Thyroid Hormone Receptor Interactor 15 Antibody
  • Thyroid Hormone Receptor Interactor15 Antibody
  • Thyroid receptor-interacting protein 15 Antibody
  • TR-interacting protein 15 Antibody
  • TRIP 15 Antibody
  • TRIP-15 Antibody
  • TRIP15 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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