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Anti-Copine-3 Antibody

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产品名称: Anti-Copine-3 Antibody
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简单介绍

Anti-Copine-3 Antibody


Anti-Copine-3 Antibody  的详细介绍
Name: Anti-Copine-3 Antibody
See all Copine-3 primary antibodies
Description: Rabbit polyclonal antibody to Copine-3
Applications: WB, IHC
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 234 and 533 of Human CPNE3
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
Tissue Specificity: Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870).
Sequence Similarities: Belongs to the copine family.
Post-Translational Modification: Phosphorylated on serine and threonine residues (PubMed:11041869).
Cellular Location: Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction > Focal adhesion.

Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870).
Database Links:
  • Entrez Gene: 8895?Human
  • Omim: 604207?Human
  • SwissProt: O75131?Human
  • Unigene: 191219?Human
    		•
    Synonyms:
  • Copine 3 Antibody
  • Copine III Antibody
  • Copine-3 Antibody
  • Copine3 Antibody
  • CopineIII Antibody
  • CPN3 Antibody
  • CPNE 3 Antibody
  • CPNE3 Antibody
  • CPNE3_HUMAN Antibody
  • KIAA0636 Antibody
  • PRO1071 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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