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Anti-COPB2 Antibody

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产品名称: Anti-COPB2 Antibody
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简单介绍

Anti-COPB2 Antibody


Anti-COPB2 Antibody  的详细介绍
Name: Anti-COPB2 Antibody
See all COPB2 primary antibodies
Description: Rabbit polyclonal antibody to COPB2
Specificity: COPB2 polyclonal antibody detects endogenous levels of COPB2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human COPB2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 102kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Sequence Similarities: Belongs to the WD repeat COPB2 family.
Cellular Location: Cytoplasm > Cytosol. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane.

The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi.
Database Links:
  • Entrez Gene: 9276?Human
  • Entrez Gene: 50797?Mouse
  • Entrez Gene: 60384?Rat
  • Omim: 606990?Human
  • SwissProt: P35606?Human
  • SwissProt: O55029?Mouse
  • SwissProt: O35142?Rat
  • Unigene: 75724?Human
  • Unigene: 400464?Mouse
  • Unigene: 37178?Rat
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    Synonyms:
  • beta COP I Antibody
  • Beta'-coat protein Antibody
  • Beta'-COP Antibody
  • Coatomer subunit beta' Antibody
  • Copb2 Antibody
  • COPB2_HUMAN Antibody
  • p102 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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