Anti-Complement C2 Antibody

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产品名称: Anti-Complement C2 Antibody

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简单介绍

Anti-Complement C2 Antibody

Anti-Complement C2 Antibody 的详细介绍

Overview

Name:	Anti-Complement C2 Antibody See all Complement C2 primary antibodies
Description:	Rabbit polyclonal antibody to Complement C2
Applications:	WB, IF
Dilutions:	Western blotting: 1:500-1:3000 Immunofluorescence: 1:100-1:200
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 265 and 612 of Human C2
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Predicted MW:	83kd
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.

Target

Background:

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Gene ID:

717

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