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Anti-COL8A2 Antibody

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产品名称: Anti-COL8A2 Antibody
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Anti-COL8A2 Antibody


Anti-COL8A2 Antibody  的详细介绍
Name: Anti-COL8A2 Antibody
See all COL8A2 primary antibodies
Description: Rabbit polyclonal antibody to COL8A2
Specificity: The antibody detects endogenous levels of total COL8A2 protein.
Applications: IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide of human COL8A2
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 0.4mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).
Tissue Specificity: Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane.
Involvement in Disease: Corneal dystrophy, Fuchs endothelial, 1: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.

Corneal dystrophy, posterior polymorphous, 2: A rare mild subtype of posterior corneal dystrophy characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic.
Post-Translational Modification: Proteolytically cleaved by neutrophil elastase, in vitro.
Cellular Location: Secreted > Extracellular space > Extracellular matrix > Basement membrane.
Database Links:
  • Entrez Gene: 1296?Human
  • Entrez Gene: 329941?Mouse
  • Omim: 120252?Human
  • SwissProt: P25067?Human
  • SwissProt: P25318?Mouse
    		•
    Synonyms:
  • AI429819 Antibody
  • COL8A2 Antibody
  • Collagen, type VIII, alpha 2 Antibody
  • FECD Antibody
  • FECD1 Antibody
  • FLJ00201 Antibody
  • MGC116970 Antibody
  • MGC116972 Antibody
  • MGC90765 Antibody
  • PPCD Antibody
  • PPCD2 Antibody
  • RP23-113P22.2 Antibody
  • RP4-665N4.3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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