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Anti-CMKLR1 Antibody

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产品名称: Anti-CMKLR1 Antibody
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Anti-CMKLR1 Antibody


Anti-CMKLR1 Antibody  的详细介绍
Name: Anti-CMKLR1 Antibody
See all CMKLR1 primary antibodies
Description: Rabbit polyclonal antibody to CMKLR1
Specificity: The antibody detects endogenous levels of total CMKLR1 protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide of human CMKLR1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.3mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Tissue Specificity: Prominently expressed in developing osseous and cartilaginous tissue. Also found in ***** parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 1240?Human
  • Omim: 602351?Human
  • SwissProt: Q99788?Human
  • Unigene: 197143?Human
    		•
    Synonyms:
  • CHEMERINR Antibody
  • Chemokine like receptor 1 Antibody
  • Chemokine-like receptor 1 Antibody
  • CHEMR23 Antibody
  • CMKLR1 Antibody
  • CML1_HUMAN Antibody
  • DEZ Antibody
  • G protein coupled receptor ChemR23 Antibody
  • G protein coupled receptor DEZ Antibody
  • G-protein coupled receptor ChemR23 Antibody
  • G-protein coupled receptor DEZ Antibody
  • Orphan G protein coupled receptor Antibody
  • Orphan G protein coupled receptor Dez Antibody
  • Resolvin E1 receptor Antibody
  • RVER1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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