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Anti-Clusterin Antibody

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产品名称: Anti-Clusterin Antibody
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Anti-Clusterin Antibody


Anti-Clusterin Antibody  的详细介绍
Name: Anti-Clusterin Antibody
See all Clusterin primary antibodies
Description: Rabbit polyclonal antibody to Clusterin
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Clusterin antibody was raised recombinant human Clusterin isoform 1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Tissue Specificity: Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
Sequence Similarities: Belongs to the clusterin family.
Post-Translational Modification: Isoform 1 is proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen.
Cellular Location: Secreted.

Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.
Database Links:
  • Entrez Gene: 1191?Human
  • Omim: 185430?Human
  • SwissProt: P10909?Human
  • Unigene: 436657?Human
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    Synonyms:
  • 40 Antibody
  • AAG 4 Antibody
  • AAG4 Antibody
  • Aging associated protein 4 Antibody
  • Aging-associated gene 4 protein Antibody
  • AI893575 Antibody
  • APO J Antibody
  • Apo-J Antibody
  • APOJ Antibody
  • ApoJalpha Antibody
  • ApoJbeta Antibody
  • Apolipoprotein J Antibody
  • ApolipoproteinJ Antibody
  • CLI Antibody
  • CLU Antibody
  • CLU1 Antibody
  • CLU2 Antibody
  • Clusterin Antibody
  • Clusterin alpha chain Antibody
  • Clusterin beta chain Antibody
  • CLUS_HUMAN Antibody
  • Complement associated protein SP 40 Antibody
  • Complement associated protein SP 40 40 Antibody
  • Complement associated protein SP40 Antibody
  • Complement cytolysis inhibitor Antibody
  • Complement cytolysis inhibitor a chain Antibody
  • Complement cytolysis inhibitor b chain Antibody
  • Complement lysis inhibitor Antibody
  • Complement-associated protein SP-40 Antibody
  • D14Ucla3 Antibody
  • Dimeric acid glycoprotein Antibody
  • Glycoprotein 80 Antibody
  • Glycoprotein III Antibody
  • GP80 Antibody
  • Ku70-binding protein 1 Antibody
  • KUB 1 Antibody
  • KUB1 Antibody
  • MGC24903 Antibody
  • NA1/NA2 Antibody
  • RATTRPM2B Antibody
  • SGP 2 Antibody
  • SGP2 Antibody
  • SP 40 Antibody
  • SP40 Antibody
  • Sugp-2 Antibody
  • Sulfated glycoprotein 2 Antibody
  • Testosterone repressed prostate message 2 Antibody
  • Testosterone-repressed prostate message 2 Antibody
  • TRPM 2 Antibody
  • TRPM-2 Antibody
  • TRPM2 Antibody
  • TRPM2B Antibody
  • Trpmb Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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