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Anti-ClpP Antibody

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产品名称: Anti-ClpP Antibody
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简单介绍

Anti-ClpP Antibody


Anti-ClpP Antibody  的详细介绍
Name: Anti-ClpP Antibody
See all ClpP primary antibodies
Description: Rabbit polyclonal antibody to ClpP
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 215 and 277 of Human CLPP
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
Tissue Specificity: Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
Involvement in Disease: Perrault syndrome 3: A sex-influenced disorder characterized by sensorineural deafness in both males and females, and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile. A spectrum of additional clinical features, including cerebellar ataxia, learning disability, and peripheral neuropathy, have been described in some PRLTS3 affected individuals.
Sequence Similarities: Belongs to the peptidase S14 family.
Cellular Location: Mitochondrion matrix.
Database Links:
  • Entrez Gene: 8192?Human
  • Omim: 601119?Human
  • SwissProt: Q16740?Human
  • Unigene: 515092?Human
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    Synonyms:
  • ATP dependent protease ClpAP (E coli) proteolytic subunit Antibody
  • ATP dependent protease ClpAP proteolytic subunit Antibody
  • ATP dependent protease ClpAP proteolytic subunit human Antibody
  • ATP dependent proteolytic subunit homolog Antibody
  • ATP dependent proteolytic subunit homolog (E coli) Antibody
  • Caseinolytic peptidase ATP dependent proteolytic subunit homolog Antibody
  • Caseinolytic protease ATP dependent proteolytic subunit E coli Antibody
  • CLPP Antibody
  • ClpP caseinolytic peptidase ATP dependent proteolytic subunit Antibody
  • ClpP caseinolytic peptidase ATP dependent proteolytic subunit homolog Antibody
  • CLPP_HUMAN Antibody
  • Endopeptidase Clp Antibody
  • mitochondrial Antibody
  • Putative ATP dependent Clp protease proteolytic subunit Antibody
  • Putative ATP dependent Clp protease proteolytic subunit mitochondrial Antibody
  • Putative ATP-dependent Clp protease proteolytic subunit Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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