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Anti-Cleaved-Caspase-9 p35 (D315) Antibody

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产品名称: Anti-Cleaved-Caspase-9 p35 (D315) Antibody
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Anti-Cleaved-Caspase-9 p35 (D315) Antibody


Anti-Cleaved-Caspase-9 p35 (D315) Antibody  的详细介绍
Name: Anti-Cleaved-Caspase-9 p35 (D315) Antibody
See all Cleaved-Caspase-9 p35 primary antibodies
Description: Rabbit polyclonal antibody to Cleaved-Caspase-9 p35 (D315)
Specificity: Cleaved-Caspase-9 p35 (D315) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-9 p35 protein resulting from cleavage adjacent to D315.
Applications: WB, IHC, IF, ELISA
Reactivity: Human
Immunogen: Synthesized peptide derived from the Internal region of human Caspase-9 p35.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Tissue Specificity: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
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