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Anti-CLDN1 Antibody

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产品名称: Anti-CLDN1 Antibody
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简单介绍

Anti-CLDN1 Antibody


Anti-CLDN1 Antibody  的详细介绍
Name: Anti-CLDN1 Antibody
See all CLDN1 primary antibodies
Description: Rabbit polyclonal antibody to CLDN1
Applications: E, WB, ICC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a 20 amino acid peptide near the carboxy terminus of human CLDN1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity).
Tissue Specificity: Detected in epididymis (at protein level). Detected in testis and epididymis.
Sequence Similarities: Belongs to the claudin family.
Cellular Location: Cell junction > Tight junction. Cell membrane. Basolateral cell membrane.

Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Database Links:
  • Entrez Gene: 9076?Human
  • Entrez Gene: 12737?Mouse
  • Entrez Gene: 65129?Rat
  • Omim: 603718?Human
  • SwissProt: O95832?Human
  • SwissProt: O88551?Mouse
  • SwissProt: P56745?Rat
  • Unigene: 439060?Human
  • Unigene: 289441?Mouse
  • Unigene: 24293?Rat
    		•
    Synonyms:
  • Claudin 1 Antibody
  • Claudin-1 Antibody
  • Claudin1 Antibody
  • CLD 1 Antibody
  • CLD1 Antibody
  • CLD1_HUMAN Antibody
  • CLDN 1 Antibody
  • Cldn1 Antibody
  • ILVASC Antibody
  • SEMP 1 Antibody
  • SEMP1 Antibody
  • Senescence associated epithelial membrane protein Antibody
  • Senescence associated epithelial membrane protein 1 Antibody
  • Senescence-associated epithelial membrane protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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