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Anti-CLCA1 Antibody

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产品名称: Anti-CLCA1 Antibody
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Anti-CLCA1 Antibody


Anti-CLCA1 Antibody  的详细介绍
Name: Anti-CLCA1 Antibody
See all CLCA1 primary antibodies
Description: Goat polyclonal antibody to CLCA1.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human CLCA1 (internal region).
Sequence: C-TVTSKTNKDTSK
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Tissue Specificity: Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
Sequence Similarities: Belongs to the CLCR family.
Post-Translational Modification: Glycosylated.
Cellular Location: Secreted > Extracellular space. Cell membrane.

Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
Database Links:
  • Entrez Gene: 1179 Human
  • Omim: 603906 Human
  • SwissProt: A8K7I4 Human
  • Unigene: 194659 Human
    		•
    Synonyms:
  • CaCC Antibody
  • CaCC-1 Antibody
  • CACC1 Antibody
  • Calcium dependent chloride channel 1 Antibody
  • Calcium-activated chloride channel family member 1 Antibody
  • Calcium-activated chloride channel protein 1 Antibody
  • Calcium-activated chloride channel regulator 1 Antibody
  • Chloride channel calcium activated family member 1 Antibody
  • Chloride channel regulator 1 Antibody
  • CLCA family member 1 chloride channel regulator Antibody
  • CLCA1 Antibody
  • CLCA1_HUMAN Antibody
  • CLCRG1 Antibody
  • GOB5 Antibody
  • hCaCC-1 Antibody
  • hCLCA1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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