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Anti-Claudin 7 Antibody

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产品名称: Anti-Claudin 7 Antibody
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简单介绍

Anti-Claudin 7 Antibody


Anti-Claudin 7 Antibody  的详细介绍
Name: Anti-Claudin 7 Antibody
See all Claudin 7 primary antibodies
Description: Rabbit polyclonal antibody to Claudin 7
Specificity: The antibody detects endogenous levels of total Claudin 7 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human Claudin 7.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Plays a major role in tight junction-specific obliteration of the intercellular space.
Tissue Specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Sequence Similarities: Belongs to the claudin family.
Post-Translational Modification: Phosphorylated.
Cellular Location: Cell membrane. Lateral cell membrane. Cell junction > Tight junction.

Co-localizes with EPCAM at the lateral cell membrane and tight junction.
Database Links:
  • Entrez Gene: 1366?Human
  • Entrez Gene: 53624?Mouse
  • Entrez Gene: 65132?Rat
  • Omim: 609131?Human
  • SwissProt: O95471?Human
  • SwissProt: Q9Z261?Mouse
  • SwissProt: Q9Z1L1?Rat
  • Unigene: 513915?Human
  • Unigene: 281896?Mouse
  • Unigene: 32259?Rat
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    Synonyms:
  • CEPTR L2 Antibody
  • CEPTRL 2 Antibody
  • CEPTRL2 Antibody
  • Claudin 1 Antibody
  • Claudin 7 Antibody
  • Claudin 9 Antibody
  • Claudin-7 Antibody
  • Claudin1 Antibody
  • Claudin7 Antibody
  • Claudin9 Antibody
  • CLD7_HUMAN Antibody
  • CLDN 7 Antibody
  • CLDN-7 Antibody
  • CLDN7 Antibody
  • Clostridium perfringens enterotoxin receptor like 2 Antibody
  • CPETR L2 Antibody
  • CPETRL 2 Antibody
  • CPETRL2 Antibody
  • Hs.84359 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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