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Anti-Clathrin Heavy Chain Antibody

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产品名称: Anti-Clathrin Heavy Chain Antibody
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Anti-Clathrin Heavy Chain Antibody


Anti-Clathrin Heavy Chain Antibody  的详细介绍
Name: Anti-Clathrin Heavy Chain Antibody
See all Clathrin Heavy Chain primary antibodies
Description: Mouse monoclonal (BF-06) antibody to Clathrin Heavy Chain.
Specificity: The antibody BF-06 recognizes clathrin heavy chain, an ubiquitously expressed 180 kDa protein involved in receptor-mediated endocytosis.
Applications: FC, IP, WB, ICC, ELISA
Reactivity: Human, Porcine, Mouse, Rat, Bovine
Host: Mouse
Clonality: Monoclonal
Clone: BF-06
Isotype: IgM
Conjugate: Unconjugated
Purification: Purified from ascites by precipitation methods and ion exchange chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 8.0, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577,PubMed:16968737). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). Plays a role in early autophagosome formation (By similarity).
Sequence Similarities: Belongs to the clathrin heavy chain family.
Cellular Location: Cytoplasmic vesicle membrane. Membrane > Coated pit. Melanosome. Cytoplasm > Cytoskeleton > Spindle.

Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
Database Links:
  • Entrez Gene: 281080 Cow
  • Entrez Gene: 1213 Human
  • Entrez Gene: 67300 Mouse
  • Entrez Gene: 54241 Rat
  • Omim: 118955 Human
  • SwissProt: P49951 Cow
  • SwissProt: P53675 Human
  • SwissProt: Q00610 Human
  • SwissProt: Q68FD5 Mouse
  • SwissProt: P11442 Rat
  • Unigene: 491351 Human
  • Unigene: 479526 Mouse
  • Unigene: 3589 Rat
    		•
    Synonyms:
  • CHC17 Antibody
  • Clathrin heavy chain Antibody
  • Clathrin heavy chain 1 Antibody
  • Clathrin heavy chain 2 Antibody
  • Clathrin heavy chain like 1 Antibody
  • Clathrin heavy chain on chromosome 17 Antibody
  • Clathrin heavy polypeptide Antibody
  • CLH 17 Antibody
  • CLH 22 Antibody
  • CLH-17 Antibody
  • CLH17 Antibody
  • CLH1_HUMAN Antibody
  • CLH22 Antibody
  • CLTC Antibody
  • CLTCL Antibody
  • CLTCL1 Antibody
  • CLTCL2 Antibody
  • CLTD Antibody
  • Hc Antibody
  • KIAA0034 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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