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Anti-CLASP1 Antibody

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产品名称: Anti-CLASP1 Antibody
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简单介绍

Anti-CLASP1 Antibody


Anti-CLASP1 Antibody  的详细介绍
Name: Anti-CLASP1 Antibody
See all CLASP1 primary antibodies
Description: Rabbit polyclonal antibody to CLASP1
Specificity: The antibody detects endogenous levels of total CLASP1 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human CLASP1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Sequence Similarities: Belongs to the CLASP family.
Cellular Location: Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle. Golgi apparatus > trans-Golgi network.

Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
Database Links:
  • Entrez Gene: 23332?Human
  • Omim: 605852?Human
  • SwissProt: Q7Z460?Human
  • Unigene: 469840?Human
  • Unigene: 708183?Human
    		•
    Synonyms:
  • 1700030C23Rik Antibody
  • 5730583A19Rik Antibody
  • B130045P17Rik Antibody
  • CLAP1_HUMAN Antibody
  • CLASP1 Antibody
  • CLIP associating protein 1 Antibody
  • CLIP associating protein CLASP1 Antibody
  • CLIP-associating protein 1 Antibody
  • Cytoplasmic linker associated protein 1 Antibody
  • Cytoplasmic linker-associated protein 1 Antibody
  • DKFZp686D1968 Antibody
  • DKFZp686H2039 Antibody
  • FLJ33821 Antibody
  • FLJ41222 Antibody
  • hOrbit1 Antibody
  • KIAA0622 Antibody
  • MAST1 Antibody
  • MGC131895 Antibody
  • mKIAA0622 Antibody
  • Multiple asters 1 Antibody
  • Multiple asters homolog 1 Antibody
  • Protein Orbit homolog 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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