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Anti-CK8 Antibody

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产品名称: Anti-CK8 Antibody
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Anti-CK8 Antibody


Anti-CK8 Antibody  的详细介绍
Name: Anti-CK8 Antibody
See all CK8 primary antibodies
Description: Mouse monoclonal antibody to CK8
Specificity: The CK8 Mouse Monoclonal antibody detects endogenous CK8 proteins.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Host: Mouse
Clonality: Monoclonal
Conjugate: Unconjugated
Purification: Affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue Specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Involvement in Disease: Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Cellular Location: Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
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