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Anti-CK-1α (Phospho-Tyr294) Antibody

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产品名称: Anti-CK-1α (Phospho-Tyr294) Antibody
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Anti-CK-1α (Phospho-Tyr294) Antibody


Anti-CK-1α (Phospho-Tyr294) Antibody  的详细介绍
Name: Anti-CK-1α (Phospho-Tyr294) Antibody
See all CK-1α primary antibodies
Description: Rabbit polyclonal antibody to CK-1α (Phospho-Tyr294)
Specificity: The antibody detects endogenous levels of CK-1α only when phosphorylated at tyrosine 294.
Applications: WB, IHC
Dilutions: Western blotting: 1:500~1:1000Immunohistochemistry: 1:50~1:100
Reactivity: Human
Immunogen: Peptide sequence around phosphorylation site of tyrosine 294 (Y-D-Y(p)-T-F) derived from Human CK-1α.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Sequence Similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Cellular Location: Cytoplasm. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Chromosome > Centromere > Kinetochore. Nucleus speckle.

Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).
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