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Anti-CIRBP Antibody

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产品名称: Anti-CIRBP Antibody
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简单介绍

Anti-CIRBP Antibody


Anti-CIRBP Antibody  的详细介绍
Name: Anti-CIRBP Antibody
See all CIRBP primary antibodies
Description: Rabbit polyclonal antibody to CIRBP
Specificity: The antibody detects endogenous level of total CIRBP antibody.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human CIRBP.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Tissue Specificity: Ubiquitous.
Post-Translational Modification: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
Cellular Location: Nucleus > Nucleoplasm. Cytoplasm.

Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
Database Links:
  • Entrez Gene: 1153 Human
  • Entrez Gene: 12696 Mouse
  • Entrez Gene: 81825 Rat
  • Omim: 602649 Human
  • SwissProt: Q14011 Human
  • SwissProt: P60824 Mouse
  • SwissProt: P60825 Rat
  • Unigene: 618145 Human
  • Unigene: 634522 Human
  • Unigene: 17898 Mouse
  • Unigene: 28931 Rat
    		•
    Synonyms:
  • A18 hnRNP Antibody
  • A18HNRNP Antibody
  • CIRBP Antibody
  • CIRBP_HUMAN Antibody
  • CIRP Antibody
  • Cold inducible RNA binding protein Antibody
  • Cold-inducible RNA-binding protein Antibody
  • Glycine rich RNA binding protein Antibody
  • Glycine-rich RNA-binding protein CIRP Antibody
  • testicular tissue protein Li 39 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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