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Anti-CIDE-A Antibody

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产品名称: Anti-CIDE-A Antibody
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简单介绍

Anti-CIDE-A Antibody


Anti-CIDE-A Antibody  的详细介绍
Name: Anti-CIDE-A Antibody
See all CIDE-A primary antibodies
Description: Rabbit polyclonal antibody to CIDE-A
Specificity: It has no cross activity to CIDE-B.
Applications: E, WB, IHC
Reactivity: Mouse
Immunogen: Raised against a peptide corresponding to amino acids 200 to 214 of mouse CIDE-A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
Tissue Specificity: Highly expressed in brown adipose tissue and, at lower levels, in white adipose tissue (at protein level). Expressed in mammary gland during pregnancy and lactation, in epithelial cells, but not in the surrounding adipose tissue. Secreted into milk via milk fat globules. Undetectable in undifferentiated preadipocytes.
Cellular Location: Lipid droplet. Nucleus.

Enriched at lipid droplet contact sites. Using a GFP-tagged construct, has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (PubMed:12910269). These data could not be confirmed (PubMed:22245780, PubMed:18509062).
Database Links:
  • Entrez Gene: 12683?Mouse
  • SwissProt: O70302?Mouse
  • Unigene: 449?Mouse
    		•
    Synonyms:
  • Cell death activator CIDE A Antibody
  • Cell Death Inducing DFFA Like Effector A Antibody
  • cell death inducing DNA fragmentation factor, alpha subunit like effector A Antibody
  • CIDE A Antibody
  • CIDE-A Antibody
  • CIDEA Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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