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Anti-CHRM2 Antibody

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产品名称: Anti-CHRM2 Antibody
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Anti-CHRM2 Antibody


Anti-CHRM2 Antibody  的详细介绍
Name: Anti-CHRM2 Antibody
See all CHRM2 primary antibodies
Description: Rabbit polyclonal antibody to CHRM2
Specificity: The antibody detects endogenous level of total CHRM2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human CHRM2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Involvement in Disease: Major depressive disorder: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
Post-Translational Modification: Phosphorylated in response to agonist treatment.
Cellular Location: Cell membrane. Cell junction > Synapse > Postsynaptic cell membrane.

Phosphorylation in response to agonist binding promotes receptor internalization.
Database Links:
  • Entrez Gene: 1129?Human
  • Entrez Gene: 243764?Mouse
  • Entrez Gene: 81645?Rat
  • Omim: 118493?Human
  • SwissProt: P08172?Human
  • SwissProt: Q9ERZ4?Mouse
  • SwissProt: P10980?Rat
  • Unigene: 535891?Human
  • Unigene: 448632?Mouse
  • Unigene: 10752?Rat
  • Unigene: 200974?Rat
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    Synonyms:
  • 7TM receptor Antibody
  • Acetylcholine receptor, muscarinic, 2 Antibody
  • AChR Antibody
  • Acm2 Antibody
  • ACM2_HUMAN Antibody
  • Cholinergic receptor muscarinic 2 Antibody
  • Cholinergic receptor, muscarinic 2, cardiac Antibody
  • Cholinergic receptor, muscarinic 2, isoform a Antibody
  • Cholinergic receptor, muscarinic 2a Antibody
  • CHRM 2 Antibody
  • CHRM2 Antibody
  • chrm2a Antibody
  • CM2 Antibody
  • FLJ43243 Antibody
  • HM 2 Antibody
  • HM2 Antibody
  • M2 Antibody
  • M2 muscarinic receptor Antibody
  • M2-mAChR Antibody
  • MGC120006 Antibody
  • MGC120007 Antibody
  • Muscarinic Acetylcholine Receptor 2 Antibody
  • Muscarinic acetylcholine receptor M2 Antibody
  • Muscarinic M2 receptor Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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