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Anti-cGKII Antibody

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产品名称: Anti-cGKII Antibody
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Anti-cGKII Antibody


Anti-cGKII Antibody  的详细介绍
Name: Anti-cGKII Antibody
See all cGKII primary antibodies
Description: Rabbit polyclonal antibody to cGKII
Specificity: cGKII Polyclonal Antibody detects endogenous levels of cGKII protein.
Applications: WB, IHC, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human cGKII around the non-phosphorylation site of S126.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Tissue Specificity: Highly concentrated in brain, lung and intestinal mucosa.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
Post-Translational Modification: Myristoylation mediates membrane localization.
Cellular Location: Apical cell membrane.
Database Links:
  • Entrez Gene: 5593?Human
  • Entrez Gene: 19092?Mouse
  • Entrez Gene: 25523?Rat
  • Omim: 601591?Human
  • SwissProt: Q13237?Human
  • SwissProt: Q61410?Mouse
  • SwissProt: Q64595?Rat
  • Unigene: 570833?Human
  • Unigene: 263002?Mouse
  • Unigene: 87721?Rat
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    Synonyms:
  • CGK 2 Antibody
  • CGK2 Antibody
  • cGKII Antibody
  • cGMP dependent protein kinase 2 Antibody
  • cGMP-dependent protein kinase 2 Antibody
  • cGMP-dependent protein kinase II Antibody
  • KGP2_HUMAN Antibody
  • PRKG 2 Antibody
  • PRKG2 Antibody
  • PRKGR2 Antibody
  • Protein kinase, cGMP dependent, type II Antibody
  • Type II cGMP dependent protein kinase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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