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Anti-CFTR Antibody

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产品名称: Anti-CFTR Antibody
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简单介绍

Anti-CFTR Antibody


Anti-CFTR Antibody  的详细介绍
Name: Anti-CFTR Antibody
See all CFTR primary antibodies
Description: Rabbit polyclonal antibody to CFTR
Specificity: CFTR Polyclonal Antibody detects endogenous levels of CFTR protein.
Applications: WB, IHC, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human CFTR around the non-phosphorylation site of S737.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Tissue Specificity: Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level).
Involvement in Disease: Cystic fibrosis: A common generalized disorder of the exocrine glands which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes. It is the most common genetic disease in Caucasians, with a prevalence of about 1 in 2'000 live births. Inheritance is autosomal recessive.

Congenital bilateral absence of the vas deferens: Important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
Sequence Similarities: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
Post-Translational Modification: Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites. Phosphorylated by AMPK.
Cellular Location: Early endosome membrane. Cell membrane.

In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia.
Database Links:
  • Entrez Gene: 1080?Human
  • Entrez Gene: 12638?Mouse
  • Entrez Gene: 24255?Rat
  • Omim: 602421?Human
  • SwissProt: P13569?Human
  • SwissProt: P26361?Mouse
  • SwissProt: P34158?Rat
  • Unigene: 489786?Human
  • Unigene: 621460?Human
  • Unigene: 661104?Human
  • Unigene: 15621?Mouse
  • Unigene: 124539?Rat
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    Synonyms:
  • ABC 35 Antibody
  • ABC35 Antibody
  • ABCC 7 Antibody
  • ABCC7 Antibody
  • ATP binding cassette sub family C member 7 Antibody
  • ATP Binding Cassette Superfamily C Member 7 Antibody
  • ATP binding cassette transporter sub family C member 7 Antibody
  • ATP-binding cassette sub-family C member 7 Antibody
  • cAMP dependent chloride channel Antibody
  • cAMP-dependent chloride channel Antibody
  • CF Antibody
  • CFTR Antibody
  • CFTR/MRP Antibody
  • CFTR_HUMAN Antibody
  • Channel conductance controlling ATPase Antibody
  • Channel conductance-controlling ATPase Antibody
  • Cystic fibrosis transmembrane conductance regulator Antibody
  • Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7) Antibody
  • Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7 Antibody
  • Cystic Fibrosis Transmembrane Regulator Antibody
  • dJ760C5.1 Antibody
  • MRP 7 Antibody
  • MRP7 Antibody
  • TNR CFTR Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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