产品资料

Anti-CFTR (E733) Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-CFTR (E733) Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-CFTR (E733) Antibody


Anti-CFTR (E733) Antibody  的详细介绍
Name: Anti-CFTR (E733) Antibody
See all CFTR primary antibodies
Description: Rabbit polyclonal antibody to CFTR (E733)
Specificity: CFTR (E733) pAb detects endogenous levels of CFTR protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 700-750 of Human CFTR.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 168 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Tissue Specificity: Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level).
Involvement in Disease: Cystic fibrosis: A common generalized disorder of the exocrine glands which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes. It is the most common genetic disease in Caucasians, with a prevalence of about 1 in 2'000 live births. Inheritance is autosomal recessive.

Congenital bilateral absence of the vas deferens: Important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
Sequence Similarities: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
Post-Translational Modification: Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites. Phosphorylated by AMPK.
Cellular Location: Early endosome membrane. Cell membrane.

In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia.
Database Links:
  • Entrez Gene: 1080?Human
  • Entrez Gene: 12638?Mouse
  • Entrez Gene: 24255?Rat
  • Omim: 602421?Human
  • SwissProt: P13569?Human
  • SwissProt: P26361?Mouse
  • SwissProt: P34158?Rat
  • Unigene: 489786?Human
  • Unigene: 621460?Human
  • Unigene: 661104?Human
  • Unigene: 15621?Mouse
  • Unigene: 124539?Rat
    		•
    Synonyms:
  • ABC 35 Antibody
  • ABC35 Antibody
  • ABCC 7 Antibody
  • ABCC7 Antibody
  • ATP binding cassette sub family C member 7 Antibody
  • ATP Binding Cassette Superfamily C Member 7 Antibody
  • ATP binding cassette transporter sub family C member 7 Antibody
  • ATP-binding cassette sub-family C member 7 Antibody
  • cAMP dependent chloride channel Antibody
  • cAMP-dependent chloride channel Antibody
  • CF Antibody
  • CFTR Antibody
  • CFTR/MRP Antibody
  • CFTR_HUMAN Antibody
  • Channel conductance controlling ATPase Antibody
  • Channel conductance-controlling ATPase Antibody
  • Cystic fibrosis transmembrane conductance regulator Antibody
  • Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7) Antibody
  • Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7 Antibody
  • Cystic Fibrosis Transmembrane Regulator Antibody
  • dJ760C5.1 Antibody
  • MRP 7 Antibody
  • MRP7 Antibody
  • TNR CFTR Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号