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Anti-CFLAR Antibody

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产品名称: Anti-CFLAR Antibody
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Anti-CFLAR Antibody


Anti-CFLAR Antibody  的详细介绍
Name: Anti-CFLAR Antibody
See all CFLAR primary antibodies
Description: Rabbit polyclonal antibody to CFLAR
Specificity: The antibody detects endogenous level of total CFLAR protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Recombinant protein of human CFLAR.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Tissue Specificity: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
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