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Anti-CFB Antibody

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产品名称: Anti-CFB Antibody
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简单介绍

Anti-CFB Antibody


Anti-CFB Antibody  的详细介绍
Name: Anti-CFB Antibody
See all CFB primary antibodies
Description: Rabbit polyclonal antibody to CFB
Specificity: CFB pAb detects endogenous levels of CFB protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human CFB.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 86 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Involvement in Disease: Hemolytic uremic syndrome atypical 4: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

Complement factor B deficiency: An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
Sequence Similarities: Belongs to the peptidase S1 family.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 629?Human
  • Entrez Gene: 14962?Mouse
  • Entrez Gene: 294257?Rat
  • Omim: 138470?Human
  • SwissProt: P00751?Human
  • SwissProt: P04186?Mouse
  • Unigene: 69771?Human
  • Unigene: 653?Mouse
  • Unigene: 109148?Rat
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    Synonyms:
  • AHUS4 Antibody
  • B factor properdin Antibody
  • BF Antibody
  • BFD Antibody
  • C3 proaccelerator Antibody
  • C3 proactivator Antibody
  • C3/C5 convertase Antibody
  • CFAB Antibody
  • CFAB_HUMAN Antibody
  • CFB Antibody
  • Complement Factor B Antibody
  • Complement factor B Bb fragment Antibody
  • Factor B Antibody
  • FB Antibody
  • FBI12 Antibody
  • GBG Antibody
  • Glycine rich beta glycoprotein Antibody
  • Glycine-rich beta glycoprotein Antibody
  • H2 Bf Antibody
  • H2BF Antibody
  • PBF2 Antibody
  • Properdin factor B Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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