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Anti-CEP164 Antibody

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产品名称: Anti-CEP164 Antibody
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简单介绍

Anti-CEP164 Antibody


Anti-CEP164 Antibody  的详细介绍
Name: Anti-CEP164 Antibody
See all CEP164 primary antibodies
Description: Rabbit polyclonal antibody to CEP164
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against an 18 amino acid peptide near the amino terminus of human CEP164.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Tissue Specificity: Expressed in several cell lines.
Involvement in Disease: Nephronophthisis 15: An autosomal recessive disorder characterized by the association of nephronophthisis with Leber congenital amaurosis and retinal degeneration, often resulting in blindness during childhood. Additional features include seizures, cerebellar vermis hypoplasia, facial dysmorphism, bronchiectasis and liver failure. Nephronophthisis is a chronic tubulo-interstitial nephritis that progresses to end-stage renal failure.
Post-Translational Modification: Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Nucleus.

Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1.
Database Links:
  • Entrez Gene: 22897?Human
  • Omim: 614848?Human
  • SwissProt: Q9UPV0?Human
  • Unigene: 504009?Human
    		•
    Synonyms:
  • AI450905 Antibody
  • BC027092 Antibody
  • CE164_HUMAN Antibody
  • Centrosomal protein 164 Antibody
  • Centrosomal protein 164kDa Antibody
  • Centrosomal protein of 164 kDa Antibody
  • CEP164 Antibody
  • D030051D21 Antibody
  • FLJ54767 Antibody
  • KIAA1052 Antibody
  • MGC38792 Antibody
  • mKIAA1052 Antibody
  • NPHP15 Antibody
  • OTTMUSP00000042044 Antibody
  • RGD1560988 Antibody
  • RGD1561243 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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