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Anti-CENPU Antibody

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产品名称: Anti-CENPU Antibody
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简单介绍

Anti-CENPU Antibody


Anti-CENPU Antibody  的详细介绍
Name: Anti-CENPU Antibody
See all CENPU primary antibodies
Description: Rabbit polyclonal antibody to CENPU
Specificity: The antibody detects endogenous levels of total CENPU protein.
Applications: IHC
Reactivity: Human
Immunogen: Full length fusion protein
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.6mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.
Tissue Specificity: Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.
Post-Translational Modification: Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.
Cellular Location: Cytoplasm. Nucleus. Chromosome > Centromere > Kinetochore.

Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
Database Links:
  • Entrez Gene: 79682?Human
  • Omim: 611511?Human
  • SwissProt: Q71F23?Human
  • Unigene: 575032?Human
    		•
    Synonyms:
  • CENP U Antibody
  • CENP-50 Antibody
  • CENP-U Antibody
  • CENP50 Antibody
  • CENPU Antibody
  • CENPU50 Antibody
  • CENPU_HUMAN Antibody
  • centromere protein of 50 kDa Antibody
  • Centromere protein U Antibody
  • FLJ23468 Antibody
  • HHV8 LNAIP1 Antibody
  • ICEN24 Antibody
  • Interphase centromere complex protein 24 Antibody
  • Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1 Antibody
  • KLIP-1 Antibody
  • KLIP1 Antibody
  • KSHV latent nuclear antigen interacting protein 1 Antibody
  • KSHV latent nuclear antigen-interacting protein 1 Antibody
  • KSHV LNAIP1 Antibody
  • LNAIP 1 Antibody
  • LNAIP-1 Antibody
  • MLF1 Interacting Protein/PBIP1 Antibody
  • MLF1-interacting protein Antibody
  • MLF1IP Antibody
  • MLF1IP1 Antibody
  • PBIP1 Antibody
  • Polo-box-interacting protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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