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Anti-CENPN Antibody

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产品名称: Anti-CENPN Antibody
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简单介绍

Anti-CENPN Antibody


Anti-CENPN Antibody  的详细介绍
Name: Anti-CENPN Antibody
See all CENPN primary antibodies
Description: Rabbit polyclonal antibody to CENPN
Specificity: The antibody detects endogenous levels of total CENPN protein.
Applications: IHC
Reactivity: Human
Immunogen: Full length fusion protein
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 3.2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Cellular Location: Nucleus. Chromosome > Centromere > Kinetochore.

Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
Database Links:
  • Entrez Gene: 55839?Human
  • Omim: 611509?Human
  • SwissProt: Q96H22?Human
  • Unigene: 726537?Human
    		•
    Synonyms:
  • BM 039 Antibody
  • BM 309 Antibody
  • BM-309 Antibody
  • BM039 Antibody
  • C16orf60 Antibody
  • CENP N Antibody
  • CENP-N Antibody
  • CENPN Antibody
  • CENPN_HUMAN Antibody
  • Centromere protein N Antibody
  • FLJ13607 Antibody
  • FLJ22660 Antibody
  • ICEN 32 Antibody
  • ICEN32 Antibody
  • Interphase centromere complex protein 32 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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