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Anti-CENPF Antibody

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产品名称: Anti-CENPF Antibody
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Anti-CENPF Antibody


Anti-CENPF Antibody  的详细介绍
Name: Anti-CENPF Antibody
See all CENPF primary antibodies
Description: Rabbit polyclonal antibody to CENPF
Specificity: The antibody detects endogenous levels of total CENPF protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human centromere protein F, 350 / 400kDa
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.4mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
Involvement in Disease: Stromme syndrome: An autosomal recessive congenital disorder characterized by intestinal atresia, ocular anomalies, microcephaly, and renal and cardiac abnormalities in some patients. The disease has features of a ciliopathy, and lethality in early childhood is observed in severe cases.
Sequence Similarities: Belongs to the centromere protein F family.
Post-Translational Modification: Hyperphosphorylated during mitosis.
Cellular Location: Cytoplasm > Perinuclear region. Nucleus matrix. Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle.

Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.
Database Links:
  • Entrez Gene: 1063?Human
  • Omim: 600236?Human
  • SwissProt: P49454?Human
  • Unigene: 497741?Human
    		•
    Synonyms:
  • AH antigen Antibody
  • Cell cycle dependent 350K nuclear protein Antibody
  • CENF Antibody
  • CENP F Antibody
  • CENP F kinetochore protein Antibody
  • CENP-F Antibody
  • CENPF Antibody
  • CENPF kinetochore protein Antibody
  • CENPF_HUMAN Antibody
  • Centromere protein F Antibody
  • Centromere protein F 350/400ka Antibody
  • Centromere protein F, 350/400kDa Antibody
  • CILD31 Antibody
  • Hcp 1 Antibody
  • Hcp1 Antibody
  • Kinetochore protein CENP F Antibody
  • Kinetochore protein CENPF Antibody
  • Mitosin Antibody
  • PRO1779 Antibody
  • STROMS Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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