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Anti-CENPE Antibody

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产品名称: Anti-CENPE Antibody
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简单介绍

Anti-CENPE Antibody


Anti-CENPE Antibody  的详细介绍
Name: Anti-CENPE Antibody
See all CENPE primary antibodies
Description: Rabbit polyclonal antibody to CENPE
Specificity: The antibody detects endogenous levels of total CENPE protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues near the N terminal of human centromere protein E, 312kDa
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.8mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity).
Involvement in Disease: Microcephaly 13, primary, autosomal recessive: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small.
Sequence Similarities: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Post-Translational Modification: The C-terminal inhibitory domain is phosphorylated. Phosphorylation relieves autoinhibition of the kinetochore motor (By similarity).
Cellular Location: Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Centromere.

Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division (By similarity). Recruited to the kinetochore in a SEPT7, CENPQ and TRAPPC12-dependent manner (PubMed:18460473, PubMed:25918224, PubMed:25395579). Recruited to the pericentromeric/centromeric regions of the chromosome in a CTCF-dependent manner (PubMed:26321640).
Database Links:
  • Entrez Gene: 1062?Human
  • Omim: 117143?Human
  • SwissProt: Q02224?Human
  • Unigene: 75573?Human
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    Synonyms:
  • CENP E Antibody
  • CENPE Antibody
  • Centromere associated protein E Antibody
  • Centromere autoantigen E Antibody
  • Centromere autoantigen E (312kD) Antibody
  • Centromere protein E Antibody
  • Centromere protein E 312kDa Antibody
  • KIF10 Antibody
  • Kinesin family member 10 Antibody
  • Kinesin related protein Antibody
  • Kinesin related protein CENPE Antibody
  • PPP1R61 Antibody
  • Protein phosphatase 1, regulatory subunit 61 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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