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Anti-CENPA Antibody

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产品名称: Anti-CENPA Antibody
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简单介绍

Anti-CENPA Antibody


Anti-CENPA Antibody  的详细介绍
Name: Anti-CENPA Antibody
See all CENPA primary antibodies
Description: Rabbit polyclonal antibody to CENPA
Applications: ELISA, IHC, WB
Reactivity: Human
Immunogen: Rabbit polyclonal CENPA antibody was raised against a peptide from a peptide from the C terminal residues of human CENPA protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity purified
Concentration: 1.0mg / ml
Formulation: PBS, pH 7.4 with 0.02% Sodium Azide
Storage: This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Function: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).
Sequence Similarities: Belongs to the histone H3 family.
Post-Translational Modification: Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.
Cellular Location: Nucleus. Chromosome > Centromere > Kinetochore. Chromosome > Centromere.

Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658).
Database Links:
  • Entrez Gene: 1058?Human
  • Omim: 117139?Human
  • SwissProt: P49450?Human
  • Unigene: 1594?Human
    		•
    Synonyms:
  • CENP A Antibody
  • CENP-A Antibody
  • CENPA Antibody
  • CENPA_HUMAN Antibody
  • Centromere autoantigen A Antibody
  • Centromere protein A Antibody
  • Centromere protein A 17kDa Antibody
  • Histone H3 like centromeric protein A Antibody
  • Histone H3-like centromeric protein A Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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