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Anti-CDK8 Antibody

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产品名称: Anti-CDK8 Antibody
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简单介绍

Anti-CDK8 Antibody


Anti-CDK8 Antibody  的详细介绍
Name: Anti-CDK8 Antibody
See all CDK8 primary antibodies
Description: Rabbit polyclonal antibody to CDK8
Specificity: The antibody detects endogenous level of total CDK8 polyclonal antibody.
Applications: IHC
Reactivity: Human
Immunogen: Recombinant human Cyclin-dependent kinase 8 protein(365-464aa)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen Affinity purified
Concentration: 1.0mg / mL
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20?C
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 1024?Human
  • Omim: 603184?Human
  • SwissProt: P49336?Human
  • Unigene: 382306?Human
    		•
    Synonyms:
  • Cdk8 Antibody
  • CDK8 protein kinase Antibody
  • CDK8_HUMAN Antibody
  • Cell Division Kinase 8 Antibody
  • Cell division protein kinase 8 Antibody
  • Cyclin Dependent kinase 8 Antibody
  • Cyclin-dependent kinase 8 Antibody
  • K35 Antibody
  • Mediator complex subunit cdk8 Antibody
  • Mediator of RNA polymerase II transcription subunit cdk8 Antibody
  • Protein kinase K35 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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