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Anti-CDK5RAP3 Antibody

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产品名称: Anti-CDK5RAP3 Antibody
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Anti-CDK5RAP3 Antibody


Anti-CDK5RAP3 Antibody  的详细介绍
Name: Anti-CDK5RAP3 Antibody
See all CDK5RAP3 primary antibodies
Description: Rabbit polyclonal antibody to CDK5RAP3
Specificity: The antibody detects endogenous levels of total CDK5RAP3 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to a region derived from internal residues of human CDK5 regulatory subunit associated protein 3
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.6mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
Tissue Specificity: Ubiquitously expressed (PubMed:12054757, PubMed:10721722). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta (PubMed:12737517).
Sequence Similarities: Belongs to the CDK5RAP3 family.
Post-Translational Modification: May be phosphorylated by CDK5.
Cellular Location: Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

Colocalizes and associates with microtubules.
Database Links:
  • Entrez Gene: 80279?Human
  • Omim: 608202?Human
  • SwissProt: Q96JB5?Human
  • Unigene: 20157?Human
    		•
    Synonyms:
  • C53 Antibody
  • CDK5 activator binding protein C53 Antibody
  • CDK5 activator-binding protein C53 Antibody
  • CDK5 regulatory subunit associated protein 3 Antibody
  • CDK5 regulatory subunit-associated protein 3 Antibody
  • CDK5RAP3 Antibody
  • CK5P3_HUMAN Antibody
  • HSF 27 Antibody
  • HSF27 Antibody
  • IC53 Antibody
  • Ischemic heart CDK5 activator binding protein C53 Antibody
  • LXXLL/leucine zipper containing ARFbinding protein Antibody
  • LZAP Antibody
  • MST016 Antibody
  • OK/SW cl.114 Antibody
  • PP1553 Antibody
  • Protein HSF-27 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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